Search results for "Klatskin tumor"

Klatskin Tumour: Meticulous Preoperative Work-Up and Resection Rate

2011

BACKGROUND: Surgery represents the only potentially curative treatment of hilar cholangiocarcinoma (hilCC). It may be suggested that meticulous preoperative work-up in Asian countries leads to higher resection rates. METHOD: One hundred and eighty-two patients treated in our department between 1998 and 2008 were included in an analysis based on our prospectively recorded database. Among them, 75 % had a percutaneous transhepatic cholangiography as part of their diagnostic work-up. A total of 160 patients underwent explorative surgery and 123 patients were resected (77 % of patients undergoing exploration, 68 % of all patients). RESULTS: Ninety-one percent of the patients were diagnosed to h…

Endoskopische ablative Verfahren bei Gallengangstumoren – Effektivität der photodynamischen Therapie und der Radiofrequenzablation

2015

Nur etwa 20–30 % der Patienten mit hilarem cholangiozellularen Karzinom (CCC) konnen bei Diagnosestellung kurativ operiert werden, da erst bei fortgeschrittenem Tumorstadium Symptome auftreten 3 . Daher konnen den meisten Patienten mit dieser Tumorentitat lediglich palliative Therapiekonzepte angeboten werden. Die Effektivitat der photodynamischen Therapie (PDT) wurde in 2 kontrolliert randomisierten sowie in weiteren kontrollierten Studien nachgewiesen. Eine endoskopische Drainage in Kombination mit einer intraluminalen PDT stellte bislang das beste palliative Therapiekonzept dar [1, 3]. Die Radiofrequenzablation (RFA) ist ein neues endoskopisches Verfahren im Rahmen des palliativen Therap…

Partial or complete mesohepatectomy combined with resection of the hilar bifurcation in cases of Klatskin tumors: a reasonable strategy?

2009

Limits of Surgical Resection for Bile Duct Cancer

2015

<b><i>Introduction:</i></b> Perihilar cholangiocarcinoma is the most frequent cholangiocarcinoma and poses difficulties in preoperative evaluation. For its therapy, often major hepatic resections as well as resection and reconstruction of the hepatic artery or the portal vein are necessary. In the last decades, great advances were made in both the surgical procedures and the perioperative anesthetic management. In this article, we describe from our point of view which facts represent the limits for curative (R0) resection in perihilar cholangiocarcinoma. <b><i>Methods:</i></b> Retrospective data of a 6-year period (2008-2014) was collected in …

Metallothionein overexpression and its prognostic relevance in intrahepatic cholangiocarcinoma and extrahepatic hilar cholangiocarcinoma (Klatskin tu…

2009

Metallothionein is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. Metallothionein has been shown to regulate apoptosis and proliferation. Overexpression of metallothionein frequently occurs in human tumors and is related to prognosis as well as therapy response. However, metallothionein expression and its clinical relevance in cholangiocarcinoma have not been investigated. The present study aimed to analyze metallothionein over-expression and its possible prognostic impact in intrahepatic cholangiocarcinoma and hilar extrahepatic cholangiocarcinoma (Klatskin tumors). We investigated the relationship of immunohistochemically demonstrated metalloth…

Cholangitis prevention in endoscopic Klatskin tumor palliation: air cholangiography technique.

2009

INTRODUCTION: Endoscopic biliary drainage is the treatment of choice for inoperable hilar cholangiocarcinoma (so-called Klatskin tumor). Cholangitis is the main complication post-endoscopic retrograde cholangiopancreatography (ERCP) in Klatskin patients, specially when medium contrast is injected into biliary tree that could not be subsequently drained. Bacterial cholangitis is the principal cause of mortality in these patients. The aim of this study is to analyze cholangitis rate resulting from the use of air versus iodine contrast to obtain cholangiography during ERCP. METHODS: In 9 years, 188 inoperable Klatskin patients were recruited and divided into two groups: iodine (A) or air (B) c…

Next-generation three-dimensional modelling software for personalized surgery decision-making in perihilar cholangiocarcinoma: multicentre study

2021

Next-generation three-dimensional modelling software for personalized surgery allows spatially accurate depiction of the hepatic and vasculature anatomy based on the complexity and individual variation in each patient, and could facilitate decision-making about preoperative strategy in perihilar cholangiocarcinoma.